Boston’s Jayson Tatum, right, drives to the basket against Chicago’s Patrick Williams, left, during the first half Monday in Boston. Charles Krupa/Associated Press

BOSTON — Jayson Tatum scored 32 points, Jaylen Brown added 19 as the Boston Celtics beat the Chicago Bulls 107-99 Monday night and reached the midway point of their season with the NBA’s best record.

Grant Williams added 20 points and Al Horford had seven rebounds and eight points, including a clutch 3-pointer with 24 seconds to play that helped seal the win for the defending Eastern Conference champions, who are 29-12 after the first 41 games.

Malcolm Brogdon scored 20 points for Boston, which played without injured point guard Marcus Smart.

Zach LaVine led Chicago with 27 points, scoring 15 in the fourth quarter while leading the Bulls’ furious comeback bid. Chicago, which had won three straight, lost DeMar DeRozan in the third quarter with a strained right quadriceps.

Nikola Vucevic had 21 points and 13 rebounds for Chicago. DeRozan finished with 13 points in 23 minutes.

A 3-pointer by LaVine pulled Chicago within 99-97 late in the fourth, but the comeback stalled when he missed a jumper in the final minute and the Celtics got the rebound to Tatum, who dribbled about 20 seconds off the clock before getting the ball to Horford for a 3-pointer. Horford’s shot bounced off the rim, then found its way through for a 104-99 lead with 24 seconds left.

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LaVine missed again for the Bulls and Tatum broke free for a two-handed dunk, drawing a foul and converting the free throw to seal it with 12 seconds remaining.

Down 11 points entering the fourth quarter, a layup by LaVine pulled Chicago within 89-84. But the Celtics answered the surge with Brown’s back-to-back jumpers and a three-point play by Williams.

The Celtics led 59-50 at halftime, matching their largest lead of the game after the Bulls committed three of their six turnovers in the final few minutes and the Celtics capitalized with a 9-2 run to close the period.

NOTES: Tatum had 10 points midway through the first quarter and scored 12 of Boston’s 28 points in the opening the period. He finished the game with seven assists and eight rebounds. … Smart left in the third quarter Saturday in a win at San Antonio after bumping knees with Zach Collins. Boston Coach Joe Mazulla said Smart’s knee was still sore Monday morning and he was considered day to day after being ruled out for Monday’s game. … Bulls guard Alex Caruso returned in the first quarter after missing the last two games with a sprained right ankle. He finished with six points.